Endocrine Abstracts

Introduction: Langerhans cell histiocytosis (LCH) is a multisystem neoplastic disease with primarily bone and skin involvement. Although its pathogenesis is still not fully understood, LCH lesions contain clonal CD 207+ dendritic cells with the frequently identified BRAF V600E mutation and an inflammatory component. Although isolated central nervous system involvement is extremely rare, a common site of involvement is the hypothalamic-pituitary axis.Case...

Pasireotide is a second-generation, multireceptor-targeted somatostatin receptor ligand and is approved for the treatment of patients with Cushing’s Didease (CD) for whom surgery has failed or is not an option. This retrospective single center study aims to report the efficacy, side effects and follow-up of the treatment with pasireotide alone or in combination with cabergoline in patients without remission after transsphenoidal surgery. Among 187 patients with CD, 15 pat...